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Prof. Dr. med. habil. Thiha Aung, MHBA (Univ.)

Professor

  • Studiengangsleiter Physician Assistant

  • Leiter des Lern- und Transferzentrum/Simulationszentrum

  • Inhaber einer Forschungsprofessur

  • Leiter der Arbeitsgruppe Translationale Sarkomforschung und Lymph-(Angiogenese) Universität Regensburg

LA 27-2.17

0991/3615-8253


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Zeitschriftenartikel

  • L. Mahl
  • J. Ollig
  • V. Schweihofer
  • L. Wiegand
  • Phillipp Torkler
  • S. Haerteis
  • Thiha Aung

Importance and implications of exosomes in nephrology and urology

In: Pflügers Archiv : European Journal of Physiology

  • 18.11.2022 (2022)

DOI: 10.1007/s00424-022-02771-y

Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their bioactive contents, including nucleic acids and proteins, exosomes can activate a variety of functions in their recipient cells. Due to the plethora of physiological and pathophysiological functions, exosomes have received a lot of attention from researchers over the past few years. However, there is still no consensus regarding isolation and characterization protocols of exosomes and their subtypes. This heterogeneity poses a lot of methodical challenges but also offers new clinical opportunities simultaneously. So far, exosome-based research is still mostly limited to preclinical experiments and early-stage clinical trials since the translation of experimental findings remains difficult. Exosomes could potentially play an important role as future diagnostic and prognostic agents and might also be part of the development of new treatment strategies. Therefore, they have previously been investigated in a variety of nephrological and urological conditions such as acute kidney injury or prostate cancer.
  • Angewandte Informatik
  • Angewandte Gesundheitswissenschaften
  • GESUND
Zeitschriftenartikel

  • I. Zucal
  • S. Geis
  • L. Prantl
  • S. Haerteis
  • Thiha Aung

Indocyanine Green for Leakage Control in Isolated Limb Perfusion

In: Journal of Personalized Medicine vol. 11

  • 05.11.2021 (2021)

DOI: 10.3390/jpm11111152

Sarcomas are characterized by a high metastatic potential and aggressive growth. Despite surgery, chemotherapy plays an important role in the treatment of these tumors. Optimal anti-cancer therapy with maximized local efficacy and minimized systemic side effects has been the object of many studies for a long time. To improve the local efficacy of anti-tumor therapy, isolated limb perfusion with high-dose cytostatic agents has been introduced in surgical oncology. In order to control the local distribution of substances, radiolabeled cytostatic drugs or perfusion solutions have been applied but often require the presence of specialized personnel and result in a certain exposure to radiation. In this study, we present a novel strategy using indocyanine green to track tumor perfusion with high-dose cytostatic therapy. In a rat cadaver model, the femoral vessels were cannulated and connected to a peristaltic pump to provide circulation within the selected limb. The perfusion solution contained indocyanine green and high-dose doxorubicin. An infrared camera enabled the visualization of indocyanine green during limb perfusion, and subsequent leakage control was successfully performed. Histologic analysis of sections derived proximally from the injection site excluded systemic drug dispersion. In this study, the application of indocyanine green was proven to be a safe and cost- and time-efficient method for precise leakage control in isolated limb perfusion with a high-dose cytostatic agent.
  • Angewandte Gesundheitswissenschaften
  • GESUND

Projekte

* AI Augmented Decision Support System **Personalisierte Medizin in der Onkologie und Nephrologie unter Einsatz von 3D-in-vivo-Modellen


Labore

*Lern- und Transferzentrum/Simulationszentrum **Lehrstuhl für Molekulare und Zelluläre Anatomie, Universität Regensburg (S1/S2 Laboren)


Kernkompetenzen

  • Facharzt für Plastische und Ästhetische Chirurgie
  • Plastisch-Rekonstruktiver Tumorchirurg
  • Mikro- und Supermikrochirugie
  • Lymphchirurgie


Forschungs- und Lehrgebiete

  • AI Augmented Decision Support System

  • Spezielle Visualisierungstechniken in der Lehre mit 3D-Anwendungen - Schwerpunkt auf virtuelle Präparationen in der Anatomie

  • Visualisierung und KI im Bereich der Angiogenese

  • Rehabilitation nach onkologischen und traumatischen Amputationen, Moderne Prothesenanpassung, Targeted-Muscle-Reinnervation (TMR) Versorgung von Prothesen

  • Translationale onkologische Forschung

  • Leiter der Arbeitsgruppe Translationale Sarkomforschung und Lymph-(Angiogenese) - siehe: https://www.uni-regensburg.de/biologie-vorklinische-medizin/molekulare-zellulaere-anatomie-haerteis/mitarbeiter/index.html

Forschung gefördert durch:

  • Deutsche Forschungsgemeinschaft (DFG)
  • Bundesministerium für Bildung und Forschung (BMBF)
  • Else-Kröner-Fresenius Stiftung
  • Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH
  • „Zentrales Innovationsprogramm Mittelstand“ des Bundesministeriums für Wirtschaft und Energie (BMWi; Projektform FuE-Kooperationsprojekte; AiF Projekt GmbH)

Bei Interesse an Bachelor-/Master-/PhD arbeiten und Medizinischen Doktorarbeiten bitte per Email anfragen.
Wir bieten:

  • Kombination aus experimenteller Forschung und klinischem Mentoring

  • Internationale Forschungsaufenthalt in Kooperation mit Harvard Medical School

  • Internationale Hospitationen und Mitwirkung bei humanitären medizinischen Hilfsprojekten

  • https://www.uni-regensburg.de/biologie-vorklinische-medizin/molekulare-zellulaere-anatomie-haerteis-1/publikationen/index.html


Vita

  • Humanmedizin-Studium an der Universität Göttingen
  • Promotion zum Dr. med. an der Universität Göttingen
  • Habilitation zum Dr. med. habil. an der Universität Regensburg
  • Facharzt für Plastische und Ästhetische Chirurgie
  • Plastisch-Rekonstruktiver Tumorchirurg
  • MHBA an der Friedrich-Alexander-Universität Erlangen-Nürnberg


Sonstiges

Auslandsaufenthalte:

  • Hospital de la Santa Creu i Sant Pau, Abteilung Plastische Chirurgie, Schwerpunkt Lymphchirurgie, Barcelona (Spanien)

  • Universitätsklinik Gent (Belgien), Department of Plastic Surgery of the University Hospital Gent - Schwerpunkt Lymphchirurgie

  • Universitätsklinik Tokyo (Japan), Abteilung Plastische Chirurgie, Schwerpunkt Rekonstruktion, Replantation und Lymphchirurgie

  • Linkou Chang Gung Memorial Hospital, Taoyan (Taiwan), Division of Plastic Reconstructive Microsurgery

  • Memorial-Sloan-Kettering Cancer Center, Department of Surgery, Orthopaedic Service, New York, USA

  • Mayo Clinic, Division of Plastic Surgery, Mayo Clinic, Jacksonville, Florida,USA

  • Harvard Medical School, Beth Israel Deaconess Medical Center, Division of Plastic and Reconstructive
    Surgery, Boston, Massachusetts, USA

Publikationen: https://www.uni-regensburg.de/biologie-vorklinische-medizin/molekulare-zellulaere-anatomie-haerteis-1/publikationen/index.html